Streptogranin antibiotics function by which of the following mechanism

USMLE Step 1 Forum

Thu, 10 Sep 2009 22:19:59 -0400

joshua

streptogranin antibiotics function by which of the following mechanism ?

a interfer with bacterial DNA synthesis

b inhibit bacterial protin synthesis

c inhibit bacterial mRNA synthesis

d inhibit bacterial adenosine triphosphatase (ATPase)

Fri, 11 Sep 2009 09:07:15 -0400

Kellie21

BB protein synthesis 50 S ribosomal subunits (specifically translocation)
Initiation- Linezolid
Peptidyl transferase- Chloramphenicol
Transpeptidation/Translocation- Macrolides ,Clindamycin, Lincomycin and Streptogramin

Fri, 11 Sep 2009 09:38:54 -0400

YouKnowWho

Fri, 11 Sep 2009 09:48:26 -0400

WilliamH

its like

Buy AT 30
CELLS at 50

A = Aminoglycosides
T Tetracyclines
C Chloramphenicol
E erythromycin
L = cLindamycin
L= Linezolid
S = Streptogramins

AT acts on 30S ribosome and CELLS acts on 50S ribosome

A and L( linezolid) blocks initiation complex
T and S interferes with aminoacid incorporation
C inhibits formation of peptide bond
E and cL blocks translocatin

hope u',l understand this..
take care

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